Physicians who received gifts from pharmaceutical companies related to opioid medications were more likely to prescribe opioids to their patients the following year, compared to physicians who did not receive such gifts, according to a new analysis led by health policy scientists at the University of Pittsburgh Graduate School of Public Health.
The research, published in the Journal of General Internal Medicine, applied statistical analysis methods in examining the relationship between gift-giving and opioid prescribing by medical specialty, as well as by pharmaceutical company.
For every 100 Americans, there were 58 opioid prescriptions written in 2017. For a country struggling with an opioid addiction epidemic, that's an alarming number.
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WHAT'S THE IMPACT
Federal law mandates that pharmaceutical companies report the dollar value of physician gift-giving, which includes meals, travel and lodging, education, consulting fees and honoraria, and "compensation for services other than consulting," alongside any product the company promotes in association with the gift.
Researchers used a Centers for Medicaid and Medicare Services database to get information on gifts given to physicians in 2014 and 2015 by pharmaceutical and medical device companies related to the promotion of opioid medications. They matched that data with Medicare data on physician prescribing of opioids in 2015 and 2016. This allowed the team to see if physicians who received gifts were more likely to prescribe opioids the following year, and if there was a link between the dollar value of the gifts and the level of prescribing. Ultimately, 236,103 physicians were included in the study.
The team then took the analysis a step further and grouped the physicians into seven broad specialty categories -- primary care, surgery, psychiatry and neurology, rehabilitative and sports medicine, hematology and oncology, pain medicine and anesthesiology, and other non-surgical specialties -- to see if the link between gifts and prescribing differed based on medical specialty.
While there was a relationship between gifts and opioid prescribing in all specialties, there was considerable variability. Primary care physicians were 3.5 times as likely to be in the highest quartile of opioid prescribing if they were paid $100 or more in gifts. Psychiatrists and neurologists who were paid $100 or more were 13 times as likely to be in the highest quartile of opioid prescribing compared to their counterparts who received less.
When the team further examined the companies behind the gifts, they found that, while 18 different companies provided gifts related to opioids, two companies -- Insys and Purdue -- were responsible for nearly two-thirds of the value of those gifts. Both have settled lawsuits for hundreds of millions of dollars related to opioid promotion and Purdue stopped marketing opioids to physicians in 2018.
However, there was great heterogeneity in which companies were marketing to which specialties -- for example, Mallinckrodt was responsible for 3% of opioid-related gifts to physicians overall, but more than half of the value of gifts to surgeons came from that company, indicating that Mallinckrodt likely targeted surgeons.
THE LARGER TREND
January research showed doctors who receive direct payments from opioid manufacturers tend to prescribe more opioids than doctors who receive no such payments. The association between payments and prescribing is strongest for hydrocodone and oxycodone, the most frequently prescribed opioids among Medicare patients.
The Medicare population is estimated to have the highest and fastest growing prevalence of opioid use disorder in the U.S.